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KMID : 1145520200060020073
Journal of Radiopharmaceuticals and Molecular Probes
2020 Volume.6 No. 2 p.73 ~ p.80
Novel mild fluorination method using light
Bui Tien Tan

Kim Hee-Kwon
Abstract
Fluorine compounds have attracted interest of scientists for immense applications in medicinal chemistry and pharmaceuticals. Recently, photoredox catalysts, both organic-based and metal-based compounds, have been employed in organic synthetic methodology to achieve desirable products due to facile operation and mild reaction condition. Various protocols to prepare fluorination adducts in the presence of photoredox catalysts have been developed from several starting materials with formation of radical scaffolds. In this review, we describe recent advances in the fluorination using light.
KEYWORD
Fluorination, radiofluorination, photoredox catalysis, light
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